Dr. Nation is from Louisville and graduated from Jeffersontown High School. She attended the University of Louisville for her Bachelor of Arts in Biology, Certificate in Clinical Laboratory Science, and her Doctorate of Dental Medicine in 2002. Dr. Karen Nation practices General Dentistry, her husband Dr. Mark Nation is a Prosthodontist here in Louisville, and they have two daughters, Shelby and Lily. Dr. Karen Nation is a strong advocate of organized dentistry and is a member of the American Dental Association, Kentucky Dental Association, and the Louisville Dental Society. She is the immediate Past President for the Louisville Dental Society and is very active in community service, both in geriatric nursing home care and pediatric care. She is actively involved in Smile Kentucky! which provides free treatment to children in need. Dr. Nation opened her state-of-the-art dental office in 2004.